Outline of the multiple experimental modalities used for the COMBAT project. SNP typing, NGS, BCT/TCR sequencing, total RNA sequencing and CyTOF were performed on whole blood. Flow cytometry, single cell ATAC sequencing and 10X CITEseq were performed on PBMC. timsTOF, luminex, serology assays and viral RNA sequencing were performed on plasma. Virus sequencing was performed on swabs. Clinical parameters for patients were recorded. Additional assays such as neutrophil and myeloid functional assays and T cell focussed assays were also performed.